Turmeric is a popular Eastern spice grown throughout India, Asia, and Central America. It has been historically used in Ayurveda medicine for many chronic conditions, such as rheumatism, pain, and fatigue. Turmeric contains an active group of polyphenolic compounds, of which curcumin is the most well studied. Curcumin is thought to have potential benefits by reducing inflammation which is the body’s response to infection or injury. The Nuclear Factor-kappaB (NF-kB) pathway serves as a pivotal mediator in the inflammatory response and is usually deregulated in chronic conditions such as atherosclerosis and diabetes. The result is prolonged inflammation that increases tissue damage. However, initial studies have explored the therapeutic benefits of curcumin, which serves as a potent mediator in NF-kB pathway reducing inflammation in varying disease states. As for the health and safety of consumption, curcumin is a generally recognized as safe compound by the Food and Drug Administration. Overall, it seems that a dose as low as 80 mg/day of curcumin can provide health benefits for a generally individual. Although gastrointestinal upset has been seen among individuals in studies consuming large quantities, further research is needed to determine the full extent of benefits, bioavailability, and dose-response of turmeric. As with any trending topic in the nutrition field, it is important to consider one’s diet rather than focusing on a single nutrient when trying to maintain a healthy lifestyle.